Wound-healing technologies: low-level laser and vacuum-assisted closure.

Chronic wounds are a major source of morbidity, lead to considerable disability, and are associated with increased mortality; therefore, they have a significant impact on public health and the expenditure of healthcare resources. The incidence of chronic wounds in the United States is approximately 5 to 7 million per year, and the annual costs for management of these wounds is greater than $20 billion. In addition, chronic wounds can lead to complications, such as infections, contractures, depression or limb amputation. These complications are associated with a need for assisted living and with higher mortality. 6 The objective of this report is to systematically review the evidence on the outcomes of two technologies for wound healing: low-level laser therapy and vacuum-assisted closure. This report addresses the following specific questions: